Floyd Mayweather and Shane Mosley will begin the USA Anti-Doping Agency (USADA) gold standard anti-doping program on Monday.

The pair are set to clash at the MGM Grand in Las Vegas on May 1, and it is the first time athletes from any U.S. professional sport have demanded World Anti-Doing Code compliant drug testing, setting both a boxing and sport precedent.

Mayweather and Mosley have agreed to the gold-standard anti-doping programme, the most stringent in sport, as outlined and mandated by USADA. The program involves no-advance-notice sample collection of the athletes' blood and urine prior to and after the fight so that all banned substances, some of which do not show up in urine alone, are tested for thoroughly, and with both athletes subjected to the testing programme leading up to as well as after the fight.

Mayweather said: "I am excited that Shane Mosley and I are willing to take these tests to ensure a fair fight on May 1.

"I just want to show the world that boxing is a clean sport and it is my hope that all fighters will take a similar stance and responsibility which reflects sportsmanship at the highest level and sets a new standard for safety in boxing."

Mosley added: "I think the testing programme is a great idea and I did not hesitate for a minute about agreeing to it. Let's hope that the rest of the boxing world follows Floyd's and my example."